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Antioxidant test for Parkinson’s disease yields disappointing results

By Cara MurezHealthDay Reporter

FRIDAY, SEPTEMBER 17, 2021 (HealthDay News) – Researchers hope to show that the natural antioxidant can delay urate Parkinson’s disease progress, but a study completed at Massachusetts General Hospital thwarted expectations.

The dissertation enrolled nearly 300 individuals recently diagnosed with early Parkinson’s disease, which affects the body’s motor system. Symptoms such as tremor, stiff limbs and balance problems progress gradually, and no medicine is known.

The research team found no significant difference in the rate of disease progression for those who gave the metabolite inosine two years compared to the placebo group.

Inosine increases urate levels in the brain and blood. It has appeared neuroprotective in preclinical models.

The inosine was not beneficial, and those who received it also had an increased dose of kidney stones, according to the study.

“The convergence of epidemiological, biological and clinical data from previous research has made a compelling argument that increasing urate, the major antioxidant circulating in the blood, can protect against the oxidative damage that is thought to play a role in Parkinson’s disease,” “says senior writer dr. Michael Schwarzschild, a neurologist at Mass General and a professor of neurology at Harvard Medical School.

“While our study did not exclude a protective effect of urate in Parkinson’s, it clearly showed that increasing urate did not slow the progression of the disease based on clinical assessments and serial exam scans,” he added.

Although it gave no answers to disease progression, Schwarzschild said the study was successful in other ways.

“The findings were very helpful in providing a reality check that now enables the field to move on to other therapeutic approaches,” Schwarzschild says. “We also learned a lot in terms of clinical trials for Parkinson’s, and ways to conduct future studies that increase their chances of success.”

The findings were published on September 14 in the Journal of the American Medical Association.

More information

The Parkinson’s Foundation has more information Parkinson’s disease.

SOURCE: Massachusetts General Hospital-Harvard University, News Release, September 14, 2021

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