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CDC-funded study shows no significant difference in COVID-19 transmission between vaccinated and unvaccinated

The Centers for Disease Control and Prevention (CDC) COVID Response Team a study published at medRxiv – a collaborative project run jointly by Cold Spring Harbor Laboratory, Yale University, and BMJ, a global healthcare knowledge provider – concluded that there is no significant difference in transmission potential of vaccinated and unvaccinated individuals using the COVID 19 “Delta variant is not infected” in federal prison during an outbreak between July and August 2021.

Dr. Jordan Peterson, a clinical psychologist, shared this on his Twitter account:

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The study showed that there were “no significant differences in the duration of RT-PCR positivity between fully vaccinated participants (median: 13 days) versus those who were not fully vaccinated (median: 13 days; p = 0.50), or in duration of culture, has been detected. positivity (median: 5 days and 5 days; p = 0.29) ”among the 95 qualifying participants out of 190, of whom 78 were fully vaccinated and 17 were not fully vaccinated.

The findings showed that “prevention and mitigation measures should be applied without regard to vaccination status for persons in high-risk environments or those with significant exposure.”

In line 336 of the study, it says:

In this investigation, we found no statistically significant difference in transmission potential between vaccinated persons and persons who were not fully vaccinated. Therefore, our findings suggest that prevention and mitigation measures should be applied without regard to vaccination status for persons in high-risk environments or those with significant exposure. In community settings, and especially correctional and detention facilities, exposure testing and quarantine remain essential tools to limit transmission when cases are identified, in addition to other recommended preventative measures. Our data contribute to a growing body of evidence characterizing the transmission potential of vaccinated individuals. Future studies of transmission potential of vaccinated individuals with infection, which include similar laboratory-based markers, as well as evidence of transmission from secondary seizure rates and network analysis, may help to further describe the contributions of vaccinated individuals in transmission chains as the pandemic develops and new variants emerge. vore.

The study confirmed that vaccinated individuals still run the risk of widespread outbreaks when the virus is introduced into community settings, even when vaccination coverage is high.

Evidence that vaccinated individuals can transmit SARS-CoV-2 to others suggests that there is a continuing risk of widespread outbreaks when the virus is introduced into community settings, even when vaccination coverage is high. In particular, due to the potential for rapid transmission and high prevalence of underlying health conditions in incarcerated populations, persons living in correctional facilities or working should be quarantined after exposure to SARS-CoV-2, regardless of vaccination status.

Line 313 of the study declare:

This report is subject to several restrictions. Due to the small proportion of participants who were not fully vaccinated (17), statistical comparisons based on vaccination status were understated, and negative findings reported here warranted careful interpretation. To increase the sample size of this group, two partially vaccinated participants were included, which possibly diluted the characteristics of unvaccinated participants. However, our conclusions did not change when analyzes were performed with the exclusion of these two participants. Similarly, only four participants knew infection beforehand, a greater proportion of which occurred in those who were not fully vaccinated; therefore, it may appear that these participants have slightly greater immunological protection than those without prior infection. On average, unvaccinated participants enrolled earlier than in the outbreak and later in their course of infection as vaccinated participants; we used Turnbull estimation in survival analyzes to consider the possibility of interval censorship in this population. All symptom data were self-reported and collected at the end of the sample collection period, which could have affected the accuracy of participants’ recall associated with the onset of symptom onset.

This article is a preview and has not been peer-reviewed, but the same authors published a similar report on Delta variant infections among inmates in a federal prison – Texas, July-August 2021 with similar findings based on the CDC website.

During a COVID-19 outbreak involving the Delta variant in a highly vaccinated captive population, transmission rates were high, even among vaccinated individuals. Although seizure rates, hospitalizations, and deaths were higher among unvaccinated than among vaccinated individuals, the duration of positive serial test results was similar for both groups. Infectious virus was grown from vaccinated and unvaccinated infected persons.

What are the implications for public health practice?

Even with high vaccination rates, maintaining multi-component prevention strategies (e.g., testing and masking for all persons and rapid medical isolation and quarantine for inmates) remains critical to limit SARS-CoV-2 transmission in community settings where physical distances are challenging. is.

A similar study by Lancet showed that people who were fully vaccinated in the UK were just as likely to spread the Covid Delta variant within households as those who were not vaccinated.

“Households are the site of most SARS-CoV-2 transmission worldwide.19 In our cohort of densely sampled household contacts exposed to the delta variant, SAR was 38% in unvaccinated contacts and 25% in fully vaccinated contacts. This finding is consistent with the known protective effect of COVID-19 vaccination against infection.8, 9 Nevertheless, these findings indicate a continued risk of infection in domestic contacts despite vaccination. ” the study said.

New study: Fully vaccinated people are just as likely to spread Delta variation within households as non-vaccinated

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